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Ultram withdrawal depression. The medication, which is classified as an opioid analgesic, is typically used to alleviate pain Sep 19, 2025 · Learn about the side effects of Ultram (tramadol), from common to rare, for consumers and healthcare professionals. Learn more about safely tapering off tramadol. Jan 29, 2023 · Learn about tramadol usage and dosing. Ultram, Ultram ER, and Conzip (tramadol) is a pain reliever (analgesic) similar to morphine used to manage moderate to moderately severe pain. Read more about the prescription drug TRAMADOL - ORAL. Nov 15, 2023 · Tramadol can cause withdrawal symptoms when you stop taking it. Like other opiate (narcotic) painkillers, Ultram is addictive and withdrawing from it can be difficult, uncomfortable and even dangerous. Reviews and ratings for Tramadol when used in the treatment of depression. Consumer information about the medication TRAMADOL - ORAL (Ultram), includes side effects, drug interactions, recommended dosages, and storage information. ULTRAM C IV (tramadol hydrochloride) Tablets WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; INTERACTIONS WITH DRUGS AFFECTING CYTOCHROME P450 ISOENZYMES; and RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS ADDICTION, ABUSE AND MISUSE We answer your top questions about tramadol including: is tramadol a narcotic, can you get addicted, and how can you safely take this drug? Feb 14, 2014 · NDC: 51655-0185-20 - MFG: 65162-627-11 - traMADOL HCL 50 MG - 20 TABLETS RX ONLY - DOSAGE: SEE PACKAGE INSERT - STORE AT 68 TO 77 DEGREES F - STORE IN A TIGHT, LIGHT-RESISTANT CONTAINER. Feb 14, 2025 · Detailed dosage guidelines and administration information for Ultram (tramadol hydrochloride). Oct 29, 2020 · Eleven patients reported significant symptoms of withdrawal upon cessation of tramadol, and five patients reported loss or reduction of libido as a side effect. ULTRAM® increases the risk of CNS and respiratory depression in these patients. Aug 15, 2023 · Ultram (tramadol) is a narcotic-like pain reliever used to treat moderate to severe pain. 243 reviews submitted with a 9. Jul 23, 2024 · Find patient medical information for Tramadol (Ultram, Conzip, Qdolo) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Oct 16, 2025 · Tramadol is an opioid medication that may be used to treat moderate to moderately severe chronic pain in adults, including pain after surgery. Ultram should not be stopped immediately, but rather tapered off with smaller and smaller doses to avoid withdrawal. WARNING: ADDICTION, ABUSE, AND MISUSE; RISK EVALUATION AND MITIGATION STRATEGY (REMS); LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; ULTRA-RAPID METABOLISM OF TRAMADOL AND OTHER RISK FACTORS FOR LIFE-THREATENING RESPIRATORY DEPRESSION IN CHILDREN; NEONATAL OPIOID WITHDRAWAL SYNDROME; INTERACTIONS WITH DRUGS AFFECTING CYTOCHROME P450 ISOENZYMES; and RISKS FROM CONCOMITANT USE Psychological effects like anxiety, depression, irritability, and intense cravings are also common with tramadol withdrawal. Understand the tramadol withdrawal timeline, detox options, and safe treatment methods. Here, we will look at the way tramadol works, the specific symptoms of tramadol withdrawal, the timeline involved, and some effective Jun 29, 2023 · Tramadol oral tablet is used to treat moderate to severe pain. In some cases, you may get relief with lower doses of each medicine. Examples of side effects of tramadol are upset stomach, constipation, and headache, but they usually are temporary. Desmetramadol eliminates common drug-drug and metabolism liabilities of tramadol (ULTRAM’s black box warnings). 5) Apr 5, 2024 · Tramadol and hydrocodone are prescribed to treat moderate to severe pain. The n-octanol/water log partition coefficient (logP) is 1. Tramadol This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. When choosing a pain reliever, doctors should keep tramadol side effects and withdrawal syndrome symptoms in mind. Apart from analgesia, ULTRAM administration may produce a constellation of symptoms (including dizziness, somnolence, nausea, constipation, sweating and pruritus) similar to that of an opioid. Desmetramadol (oral or parenteral) is the M1 metabolite and does not require metabolism for activity. Learn side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more. Therefore, its use is restricted to cases of pain refractory to other medications, such as nonopioid pain medication Oct 4, 2023 · The petitioner has identified no data or other information suggesting that ULTRAM (tramadol hydrochloride) Tablets, 50 mg, was withdrawn for reasons of safety or effectiveness. Withdrawal from tramadol can result in both symptoms typical of opioid withdrawal and those associated with SNRI withdrawal. Jul 11, 2022 · Ultram is used to treat and manage moderate to severe pain. Sep 5, 2025 · Get the facts about opiates (narcotics) to see if they are the right treatment for your fibromyalgia or chronic fatigue syndrome pain. Oct 8, 2024 · Symptoms of tramadol withdrawal can start 8-24 hours after the last dose. This article delves into the complex relationship between Tramadol and brain function, exploring whether this medication can cause permanent brain damage and what users should know about Oct 1, 2025 · Description Tramadol and acetaminophen combination is used to relieve acute pain severe enough to require an opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. While it is considered safer than traditional opioids, growing concerns have emerged regarding its adverse psychological effects. Between 1995 and 2000, 422 cases of withdrawal were reported by physicians, or nearly 100 a year, and this was a third of all adverse events reported However, tolerance, withdrawal and Drug Seeking Behavior also occur with Tramadol Desmethyltramadol (O-DSMT), is a Mu opioid Agonist, and Tramadol is regulated as an Opioid Analgesic. Learn more about the timeline of withdrawal, treatment options, and symptoms you might experience. Prolonged use of ULTRAM, during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life threatening if not recognized and treated If prolonged opioid use is required in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. Since July 2014, the FDA has classified tramadol as a class IV controlled substance due to its potential for misuse and addiction. As its usage has increased over the years, so have concerns about its potential long-term effects on brain health. About generic Ultram Tramadol (Ultram) is an inexpensive drug used to treat moderate to severe pain in adults. When compared dose-by Sep 28, 2021 · Tramadol is an opioid prescribed by physicians as a painkiller for treating moderate to moderately severe pain. Ultram (Tramadol) Withdrawal Tramadol withdrawal is very similar to other opiate medications but comes with some differences as a result of its effects on serotonin and norepinephrine. Symptoms of tramadol withdrawal can begin as soon as 12-24 hours after taking the last dose. These symptoms may include: anxiety, sweating, insomnia, rigors, pain, nausea, tremors, diarrhea, upper respiratory symptoms, piloerection and rarely hallucinations. ULTRAM C IV (tramadol hydrochloride) Tablets WARNING: ADDICTION, ABUSE, AND MISUSE; RISK EVALUATION AND MITIGATION STRATEGY (REMS); LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; ULTRA-RAPID METABOLISM OF TRAMADOL AND OTHER RISK FACTORS FOR LIFE-THREATENING RESPIRATORY DEPRESSION IN CHILDREN; NEONATAL OPIOID WITHDRAWAL SYNDROME; INTERACTIONS WITH DRUGS AFFECTING CYTOCHROME P450 Oct 4, 2024 · Tramadol is an atypical opioid with a withdrawal syndrome slightly different than that of most opioids. 9 In a medical setting, detox from tramadol and other opioids aims to: 9 Reduce the pain and discomfort of withdrawal symptoms. Beyond the common symptoms like nausea, sweating, and muscle pain, withdrawal syndrome can include symptoms such as severe anxiety, depression, and irritability. It can be hard to stop! Looking for reliable pain relief? Learn where to buy Tramadol online safely with a prescription. Reduce relapse Tapering off tramadol after long-term use should be approached with caution and medical supervision, as withdrawal symptoms can vary in intensity and duration based on individual factors, including the length of use, dosage, and personal health history. It works by reducing substances in the body that causes pain. Tramadol withdrawal causes symptoms like nausea, muscle aches, and cravings. May 14, 2015 · Choosing Wisely Recommendations Don’t prescribe tramadol for older adults without considering the potential risks and harms related to serotonergic excess, seizures, falls, and drug-drug The molecular weight of tramadol HCl is 299. Tramadol withdrawal is caused by stopping the drug suddenly. Jun 16, 2025 · Ultram ER package insert / prescribing information for healthcare professionals. The severity of withdrawal may depend on: The dose you are taking Whether you are physically dependent on it Being physically dependent on a drug means you need to take it to prevent unpleasant symptoms Prolonged use of ULTRAM during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated. (5. ULTRAM ER tablets contain 100, 200 or 300 mg of tramadol HCl in an extended-release formulation. Apr 5, 2022 · Evidence indicates that low-dose tramadol is a generally safe, effective, and fast-acting antidepressant for a substantial number of individuals suffering from depression. [13][17] When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. [13] It is also available by injection. Tramadol is in a class of medications called opiate (narcotic) analgesics. As an opioid, there is the risk of dependence and withdrawal on stopping. Contrary to earlier belief, chronic tramadol use can result in opioid addiction. Clinical experience suggests that tapering the dose may relieve withdrawal symptoms. In contrast to morphine, tramadol has not been shown to cause histamine release. Dec 4, 2024 · Tramadol is an opioid used to treat pain. The tablets are white to off-white in color and contain the Jun 20, 2024 · Many medications are recommended to avoid anxiety and depression. Learn more about the tramadol withdrawal timeline and how to get help. Jul 23, 2025 · Tapering schedules can help to minimize withdrawal symptoms related to tramadol use. Learn more about tramadol withdrawal. Aug 1, 2025 · Learn about the opioid, tramadol--including facts, history, statistics on use and misuse, laws, and how to find tramadol addiction treatment. Prolonged use of ULTRAM during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated. Ultram Withdrawal: Symptoms and Timeline Stopping Ultram suddenly can trigger withdrawal, which may be severe and uncomfortable. Sep 15, 2017 · Before taking tramadol, be sure to inform your doctor if you have kidney disease, cirrhosis or other liver disease, a stomach disorder, or a history of depression and mental illness, the Mayo Feb 17, 2020 · Accidental ingestion of even one dose of tramadol, especially by children, can result in a fatal overdose of tramadol. Seizures Desmetramadol Tramadol (ULTRAM) is approved for moderate to moderately severe pain but requires metabolism in the body to its M1 metabolite for activity. CONTRAINDICATIONS: ULTRAM ER should not be administered to Jul 30, 2025 · Learn more about the prescription opioid tramadol and tramadol addiction, including how to find treatment if you're struggling with misuse. The tablets are white to off-white in color and contain the Explore tramadol’s impact on mood, including emotional dependence, serotonin disruption, and why medical detox is crucial for lasting recovery and mental clarity. Serious potential consequences of overdosage with ULTRAM® (tramadol hydrochloride) tablets are central nervous system depression, respiratory depression and death. Tramadol belongs to the Tramadol is a prescription painkiller that has both opioid and non-opioid actions. breastfeeding. Symptoms may include anxiety, sweating, insomnia, rigors, pain, nausea, tremors, diarrhea, upper respiratory symptoms, piloerection, and, rarely, hallucination. But how does it work? Are there any side effects associated with it? Keep reading to learn more about the safety and effectiveness of Tramadol for anxiety and depression. Take Ultram Tablet by mouth as directed by your doctor. Compare Tramadol vs Ultram head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Withdrawal: mentioned by 15 users (6. ULTRAM® should be used with caution and in reduced dosages when administered to patients receiving CNS depressants such as alcohol, opioids, anesthetic agents, narcotics, phenothiazines, tranquilizers or sedative hypnotics. Tramadol is a popular opioid pain medicine that’s sold in the States under the name Ultram. Generic tramadol is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. It is a white, bitter, crystalline and odorless powder that is readily soluble in water and ethanol and has a pKa of 9. WARNING: ADDICTION, ABUSE, AND MISUSE; RISK EVALUATION AND MITIGATION STRATEGY (REMS); LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; ULTRA-RAPID METABOLISM OF TRAMADOL AND OTHER RISK FACTORS FOR LIFE-THREATENING RESPIRATORY DEPRESSION IN CHILDREN; NEONATAL OPIOID WITHDRAWAL SYNDROME; INTERACTIONS WITH DRUGS AFFECTING CYTOCHROME P450 ISOENZYMES; and RISKS FROM CONCOMITANT USE ULTRAM C IV (tramadol hydrochloride) Tablets WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; ULTRA-RAPID METABOLISM OF TRAMADOL AND OTHER RISK FACTORS FOR LIFE THREATENING RESPIRATORY DEPRESSION IN CHILDREN; NEONATAL OPIOID WITHDRAWAL SYNDROME; INTERACTIONS WITH DRUGS AFFECTING CYTOCHROME P450 ISOENZYMES; and RISKS FROM CONCOMITANT USE WITH ULTRAM® [UHL-tram] (tramadol hydrochloride) Tablets, C-IV ULTRAM is: A strong prescription pain medicine that contains an opioid (narcotic) that is used for the management pain in adults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them. • Patients taking Ultram may develop dependence and experience withdrawal symptoms when discontinuing 10 it. Your doctor will discuss the potential benefits, side effects, and risks of each drug. Ultram is an opioid analgesic for the treatment of severe pain in adults when alternative treatment are inadequate. Untreated, withdrawal symptoms usually last for 4-10 days. 2%) patients who reported a dose consumed experienced relief from depression at low therapeutic doses (25–150 mg/day). Tramadol releases some of the same components as do many SSRI anti-depressants. Attempting to stop consuming tramadol abruptly is often tied to severe withdrawal symptoms and complications. Includes dose adjustments, warnings and precautions. It is available in generic and brand versions. 2%) patients who reported a dose consumed experienced relief from depression at low therapeutic doses (25-150 mg/day). It works similar to morphine. Jul 29, 2024 · Explore the connection between tramadol and anxiety, treatment options, and management strategies for anxiety-prone individuals. The psychological and physical pain associated with withdrawal symptoms during opioid detox often leads to The molecular weight of tramadol HCl is 299. Ultram’s unique action on serotonin and norepinephrine means that withdrawal and overdose risks can be higher for certain individuals, especially those with mental health conditions or those taking antidepressants. Jul 14, 2025 · Tramadol withdrawal symptoms can range from mild to severe. Tramadol is among those medicines. Withdrawal Symptoms Withdrawal symptoms may occur if tramadol is discontinued abruptly. When used together, the combination provides better pain relief than either medicine used alone. Prolonged use of ULTRAM ER during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated. Precautions and considerations for taking Tramadol Tramadol is not to be taken unless strictly recommended and prescribed by a medical doctor. We have carefully reviewed our files for records concerning the withdrawal of ULTRAM (tramadol hydrochloride) Tablets, 50 mg, from sale. It comes in immediate-release and extended-release forms. Tramadol extended-release tablets and capsules should not be used to treat mild or moderate pain, short-term pain, or pain that can be controlled by medication that is taken as needed. All user comments are moderated by Drugs. 6%) Based on user experiences from 229 Ultram reviews, the following table shows the most commonly mentioned side effects. Includes: indications, dosage, adverse reactions and pharmacology. com. Tramadol is an opioid analgesic drug used to treat moderate to moderately severe pain. Dec 1, 2010 · Acute overdosage with tramadol can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils Jan 24, 2021 · Tramadol is an opioid painkiller, and while fairly weak compared to morphine and heroin can still produce very unpleasant or even painful withdrawal symptoms. Withdrawal symptoms may occur if tramadol hydrochloride is discontinued abruptly. This systematic review examined tramadol-induced psychological side effects, identified risk factors, and evaluated possible underlying mechanisms that might help to Nov 12, 2024 · Official answer: Tramadol, an opioid used for pain, has a long list of serious (bad) side effects. He or she will weigh up benefits against potential complications and likely side-effects before prescribing the use of Jul 18, 2024 · Tramadol detox can be a difficult process. It works by changing the way the brain and nervous system respond to pain. Learn about side effects, warnings, and more. Each review is verified for relevance and screened for inappropriate content. Most (57/72, 79. Tramadol can be highly addictive, and if you stop taking the drug abruptly it may cause withdrawal symptoms. Side effects are user-reported and not clinically verified. Feb 1, 2024 · Tramadol is an opioid medication that may cause withdrawal after long-term use. Our expert guide is available 24/7 to help you manage your pain effectively Aug 4, 2025 · Tramadol, a prescription painkiller, can cause withdrawal in dependent individuals, sometimes leading to serious atypical symptoms. Ultra-rapid metabolism of tramadol and other risk factors for life-threatening respiratory depression in children: Life-threatening respiratory depression and death have occurred in children who received tramadol. Aug 8, 2024 · Thinking of quitting drugs or alcohol? Be aware of and learn how to deal with withdrawal symptoms such as feelings of depression and anxiety. Jul 11, 2024 · Tramadol is a widely prescribed opioid medication used for managing moderate to severe pain. 2 average score. Some of the most serious side effects Nov 7, 2024 · Learn how to get off tramadol safely and effectively, and find out why quitting it abruptly or without medical supervision is never a good choice. Here is everything you need to know about withdrawal symptoms, your timeline, and how to get help. The tablets are white to off-white in color and contain the Serious potential consequences of overdosage with ULTRAM® (tramadol hydrochloride) tablets are central nervous system depression, respiratory depression and death. Your doctor will have done a thorough assessment of your specific condition before determining treatment with Tramadol as an option. Feb 20, 2024 · Tramadol is approved by the US Food and Drug Administration (FDA) as a pain relief medication, specifically indicated for moderate-to-severe pain. It’s typically used to treat pain ranging from the moderate to the severe and is sometimes given to treat chronic pain. Learn why tramadol is prescribed here. Tramadol releases serotonin, just like depression medication and inhibits the re-uptake of nor-epinephrine like depression treatment; but does it release enough and is it safe to give Tramadol as a treatment for depresion? Tramadol The molecular weight of tramadol HCl is 299. Learn what to expect during the tramadol withdrawal timeline. Feb 18, 2025 · Tramadol is a synthetic opioid widely used in clinical practice to treat moderate to severe pain. Tramadol, sold under the brand name Tramal among others, [17][1] is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderate to severe pain. Gain insights on managing pain and depression in patients taking tramadol. This drug is more popular than comparable drugs. Tramadol is a synthetic opioid painkiller, and withdrawal from opioids can be challenging. At therapeutic Sep 19, 2025 · Learn about the side effects of tramadol, from common to rare, for consumers and healthcare professionals. 41. 5) Tramadol Information Tramadol is a specific type of narcotic medicine called an opioid that is approved to treat moderate to moderately severe pain in adults. Aug 18, 2025 · How to Cope with Tramadol Withdrawal Symptoms Though often very intense, in most cases tramadol and other opioid withdrawal is not life-threatening. Tramadol usually takes about an hour to take effect when taken in tablet or suppository form and just minutes when injected directly into the bloodstream. Food and Drug Administration Ultram Tablet effectively relieves moderate to severe pain in conditions like menstrual cramp, arthritis, headache, muscle aches if taken when the first signs of pain occur. Includes Ultram side effects, interactions and indications. Dec 7, 2017 · Tramadol and Vicodin are powerful pain relievers. What is Tramadol used for? Tramadol (pronounced Tra-ma-dole), also known by brand names Ultram, Ultram ER, Ralivia, Dromodol, Ryzolt, ConZip, Rybix ODT and FusePaq Synapryn, is commonly prescribed to treat neuropathic pain and various disorders characterised by tender, painful and stiff muscles. However, tramadol causes less respiratory depression than morphine at recommended doses (see OVERDOSAGE). Sep 26, 2016 · Tramadol is used to treat moderate pain. This gives relief from pain and discomfort and thus improves the quality of your life. Moreover, sudden discontinuation of the medication can increase the chances of complications like seizures, making medically supervised tapering a better option for most individuals. Eleven patients reported significant symptoms of withdrawal upon cessation of tramadol, and five patients reported loss or reduction of libido as a side effect. Learn the symptoms. Tramadol may cause both psychological and physical dependence. Jun 25, 2014 · Tramadol Withdrawal Duration: How long will it last? Most individuals report that the bulk of their withdrawal from Tramadol lasts anywhere from 10 days to a few weeks. Symptoms normally seen in tramadol withdrawal according to their prevalence are as follows: gastrointestinal pain, anxiety, bone pain, depression, diarrhea, insomnia, epiphora, nausea, agitation, rhinorrhea, excessive perspiration. 8. However, it is important to understand that many people also experience what is known as post acute withdrawal syndrome (PAWS). Dec 1, 2010 · Rebel Distributors Corp: ULTRAM ER is indicated for the management of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of their pain for an extended period of time. Desmetramadol is proven in Feb 14, 2025 · Side Effects and Withdrawal Syndrome During tramadol withdrawal, patients may experience a variety of side effects that range from mild to severe. Studies have been conducted to see if Tramadol can be used to treat depression. 9 Medical detox can help keep you as safe and comfortable as possible while easing distressing symptoms. Find out how they work, how they compare, and why you should take them with caution. Jul 11, 2024 · Explore the complex relationship between tramadol and depression, including potential mechanisms, benefits, risks, and treatment options. [18] It is available in combination with Feb 19, 2025 · Ultram package insert / prescribing information for healthcare professionals. It also has additional interactions that can cause very strong psychological withdrawal symptoms. 35 at pH 7. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. fpl ysapz fnmhu 7f9 qn ait60 tt2 mtlq w7 eecpjmh